Prize Competitions
Redesign Dialysis, Phase 1
Total prize amount:$1.125 Million
KidneyX’s inaugural prize competition, Redesign Dialysis, asked innovators to accelerate the development and commercialization of next-generation dialysis products.
Goals
- Sought solutions or components of solutions that could offer patients significant alternatives to dialysis
- Attracted a wide range of ideas and participants to catalyze development of new, improved classes of renal replacement therapy options
Projected Impact
Shift the paradigm for how kidney failure is managed
Winners
An Air Removal System or a Wearable Renal Therapy DeviceMorteza Ahmadi and Clarence Graansma, Qidni LabsAn automatic air removal system that can be used safely in a wearable renal therapy device with minimal user intervention
A Non-Invasive, Wearable Telehealth Device to Detect Thrombosis and Monitor Vascular Access Health of Arteriovenous Fistulas and Grafts in Hemodialysis PatientsVinay Narasimha Krishna, Mohammad R. Haider, and Steven D. Gardner, University of Alabama at BirminghamA sensor-based wearable device to detect hemodialysis vascular access clotting in real time to expedite time to intervention, thereby reducing morbidity and mortality
Atomically Precise Membranes (APM) for High-Flux and Selective Removal of Blood ToxinsChristian Schafmeister, Yihui Xie, and Avner Ronen, Temple UniversityChemically synthesized, atomically precise membranes that can be as thin as a single molecule that mimic the highly permeable and selective membrane channels present in human cells
Building New KidneysMiromatrix Medical Inc.Using multiple patented technologies, Miromatrix is working to bioengineer new kidney grafts that consist of human cells grown in pig extracellular matrix (ECM) scaffolds.
Development of a Dialysate- and Cell-Free Renal Replacement TechnologyIra Kurtz, UCLA; Roland Ludlow, Curion Research Corporation; Jamie Hestekin, University of ArkansasNovel technology for use in KRT devices that employs ultrafiltration and ion/water transport capabilities but does not use external water/dialysate or living cells
Development of an Automated Multimodal Sensor to Improve Patient Outcomes in HemodialysisOutset MedicalAutomated means of monitoring important physiological parameters during hemodialysis particularly for use in in-home or in-center self-care hemodialysis
Digitally Delivered Behavior Change Program to Help Patients Delay DialysisBinnovate Digital Health BVA cost-effective, patient-centered, digital therapeutic that aims for the best possible individual prognosis for each CKD patient, as well as to delay dialysis in ESRD patients
Displacer-Enhanced Hemodialysis: Improving the Intradialytic Removal of Protein-Bound Uremic Toxins Using Binding CompetitorsRenal Research Institute LLCUse of a displacer substance in a dialysis machine’s blood tubing which binds to the same binding sites on albumin as the toxins, making them easier to remove
Drug-Eluting Electrospun Hemodialysis GraftYael Vin and Nikhil Agrawal, Beth Israel Deaconess Medical Center; Matthew Phaneuf, BioSurfaces LLCIncorporate drugs into a synthetic electrospun graft to help reduce the failure and infection common with biologic grafts
Fluo Medical Fistula Monitoring DeviceDimitri Augustin and Racquel Redwood, Stanford UniversityWearable, real-time monitor of arteriovenous fistula attributes that identifies failing or properly maturing arteriovenous fistulas to help make earlier informed treatment decisions
Intracorporeal Hemodialysis SystemShuvo Roy, UC San Francisco; William H. Fissell, Vanderbilt University; Charles Blaha, Silicon KidneyA hemodialysis system that uses a compact hemodialyzer to create permanent internal vascular connections to eliminate needle-based vascular access and improve patient outcomes
Nitric Oxide-Eluting, Disposable Hemodialysis Catheter Insert to Prevent Infection and ThrombosisAlexander Yevzlin, Shaker Qaqish, and Mark Meyerhoff, University of Michigan; John Zentgraf, J. Zentgraf Product Development ConsultingInnovative NO releasing catheter insert device for hemodialysis to help decrease infections and other complications, which in turn reduce hospitalizations, morbidity, and mortality
Smart Sensor-Enhanced Needle Guide Reduces Pain and Cost in ClinicRoger Mason and Daniel Nadis, Access for Life, Inc.Sensor-enhanced needle guide reduces pain from large bore needles, limits damage to the surrounding fistula wall, and helps identify increased stenosis risk during hemodialysis
The Ambulatory Kidney to Improve Vitality (AKTIV)Jonathan Himmelfarb, Buddy Ratner, Larry Kessler, Kassandra Thomson, Glenda V. Roberts, and Anna Galperin, University of Washington Center for Dialysis InnovationA wearable, miniaturized dialysis system that is low-cost, water-efficient, and patient friendly; requires minimal anticoagulation; and offers complication-free blood access
Utilizing Optical Interrogation Methods for Early Diagnosis of Peritonitis in Peritoneal Dialysis PatientsMark Buckup, Alisha Birk, and Janelle Kaneda, Stanford University Bioengineering DepartmentOpticLine helps to detect early indicators of developing peritonitis to reduce risk of infection, prevent scarring of the peritoneum, and lower acute hospitalization costs
