Honorable Mention Development of a Dialysate-Free Wearable and Implantable Artificial Kidney

Current clinical approaches to treat patients with end stage renal disease (ESRD) include hemodialysis, peritoneal dialysis, and renal transplantation. Here we describe the design and operation of a novel technology that has the potential to mimic the filtration properties of the renal glomerulus and the ion/water transport processes in the nephron. The technologic advances and approaches employed in this proposal can be potentially utilized in various configurations that include standalone, wearable and implantable artificial kidney devices to treat patients with compromised kidney function. The device couples for the first time new multiple mesh electro-deionization technology with pressure driven ultrafiltration, nanofiltration and reverse osmosis modules specifically developed for this project. Importantly, the device does not utilize external water/dialysate or living cells. The technology we describe represents a significant advance in the field of renal replacement therapy ever since dialysis was first developed as a therapeutic modality over 70 years ago. We have initiated animal testing of our current wearable artificial kidney device. In two-years we will have completed the proof of concept phase of animal testing in preparation for the FDA and clinical trials.

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