Honorable Mention: Development, Characterization and Functional Assessment of Mobile & Modular Microfluidic Dialysis Device Delivery (M3D3 Unit) Artificial Kidney
Objective: To improve HD delivery by introducing the M3D3 AK which is based on a disruptive platform called "Microfluidic Capillaries & Lymphatic Tech." (MCAL) to replace the 50-year old Hollow Fiber Tech. (HFT). Utilizing this proprietary modular and microfluidic platform, we can fabricate tiny dialyzers called "Dialyzer-on-Chip" (DOC). DOCs will drastically enhance the removal of clinically significant Uremic Toxins (UTs) which makes the M3D3 highly efficient and compact to be wearable. Thus, will lead to significantly improved and highly efficient dialysis therapies with reduce morbidity and mortality of the ESRD patients.
Approach: The patented MCAL platform is used to make many different unique and modular "multilayered microfluidic microdialyzers"- DOCs. These DOCs are created by sandwiching different semipermeable membranes (SPMs) with diverse permeabilities in between the microfluidic layers each containing hundreds to thousands of microchannels and seal them together to generate multitude of microtunnels. Also, to emulate different parts of a nephron, these DOCs are created using different SPMs with wide-ranging permeabilities to perform all forms of dialysis processes such diffusion, convection, ultrafiltration etc. Due to modularity of DOCs, they can be joined together in parallel and/or in series to develop many diverse dialysis devices capable of performing all variety of Renal Replacement Therapies including but not limited to osmosis, ultrafiltration, hemodialysis, albumin dialysis, hemodiafiltration etc. Lastly, these DOCs containing numerous microtunnels will replace the highly inefficient HFT dialyzers now in clinical use. By shifting the diffusive and convective processes from a larger distance (100 um radius of HF) to a much smaller distance (20 um radius of microtunnels). By reducing the diffusion distance, the clearance of UTs occur very rapidly and ultimately becoming highly efficient based on the inverse relationship between diffusion time and the diffusion distance squared. Theoretically, the efficiency can be improved by 2500% [(100/20)2 = 25]!
To learn more, please email Mordechai S. Nosrati, MD at email@example.com.